期刊
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
卷 46, 期 5, 页码 819-821出版社
OXFORD UNIV PRESS
DOI: 10.1093/jac/46.5.819
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The metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France was determined using a neonatal mouse model and compared with the outcome in patients after standard metronidazole therapy (0.75 g/day for 5 days), All isolates found to be clinically resistant to metronidazole (4/11) exhibited an ID50 > 120 mg/kg in the mouse model. This therefore appears to be a suitable animal model in which to explore drug failures in human giardiasis.
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