期刊
RADIOLOGY
卷 217, 期 2, 页码 487-493出版社
RADIOLOGICAL SOC NORTH AMER
DOI: 10.1148/radiology.217.2.r00nv10487
关键词
coronary vessels, flow dynamics; coronary vessels, MR; coronary vessels, stenosis or obstruction; magnetic resonance (MR), cine studies; magnetic resonance (MR), experimental studies; magnetic resonance (MR), vascular studies; myocardium. blood supply
PURPOSE: To validate coronary sinus flow measurements for quantification of global left ventricular (LV) perfusion by means of velocity-encoded cine (VEC) magnetic resonance (MR) imaging and flow probes. MATERIALS AND METHODS: Measurements of coronary sinus flow were performed in seven dogs by using VEC MR imaging at baseline, single coronary arterial stenosis, dipyridamole stress, and reactive hyperemia. These measurements were compared with flow probe measurements of coronary blood flow (CBF) in the left anterior descending coronary (LAD) and circumflex (CFX) arteries (CBFLAD+CFX) and coronary sinus. LV blood perfusion was calculated in milliliters per minute per gram from coronary sinus flow, and LV mass was obtained by using VEC and cine MR imaging. LV mass was validated at autopsy. RESULTS: CBFLAD+CFX and coronary sinus flow at VEC MR imaging showed close correlation (r = 0.98, P < .001). The difference between CBFLAD+CFX and MR coronary sinus flow was 3.1 mL/min +/- 8.5 (SD). LV mass at cine MR imaging was not significantly different from that at autopsy (73.2 g +/- 12.8 vs 69.4 g +/- 12.8). At baseline, myocardial perfusion was 0.40 mL/min/g +/- 0.09 at VEC MR imaging, and CBFLAD+CFX was 0.44 ml/min/g +/- 0.08 (not significant). Reactive hyperemia resulted in 2.7- and 2.3-fold increases in coronary sinus flow at VEC MR imaging and flow probe CBFLAD+CFX respectively. CONCLUSION: VEC MR imaging has the potential to measure coronary sinus flow during different physiologic conditions and can serve as a noninvasive modality to quantify global LV perfusion in patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据