期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 111, 期 2, 页码 498-500出版社
WILEY
DOI: 10.1046/j.1365-2141.2000.02403.x
关键词
nitric oxide; L-arginine; sickle cell disease; vaso-occlusive crisis; nitric oxide metabolites
类别
资金
- NCRR NIH HHS [RR01271-19] Funding Source: Medline
- NHLBI NIH HHS [HL-20985] Funding Source: Medline
To determine the effects of l-arginine (l-Arg) supplementation on nitric oxide metabolite (NOx) production, oral l-Arg was given to normal controls, sickle cell disease (SCD) patients at steady state and SCD patients hospitalized with a vaso-occlusive crisis (VOC). l-Arg (0.1 g/kg) increased NOx formation by 18.8 +/- 68% in normal controls, whereas steady-state SCD patients demonstrated a paradoxical decrease in NOx of -16.7 +/- 4% (P = 0.004). In contrast, patients with VOC demonstrated a dramatic increase in NOx production by +77.7 +/- 103%, a response that was dose dependent. l-Arg appears to be the rate-limiting step in NOx production during VOC. Oral arginine may therefore benefit SCD patients by inducing an increase in NO production during VOC.
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