期刊
BIOINFORMATICS
卷 25, 期 14, 页码 1843-1845出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btp272
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资金
- National Natural Science Foundation of China [30770499, 10721403]
- Wallace H. Coulter GaTech/Emory-PKU BME Collaborative Research Seed Grant Program
We proposed a tool named MetaTISA with an aim to improve TIS prediction of current gene-finders for metagenomes. The method employs a two-step strategy to predict translation initiation sites (TISs) by first clustering metagenomic fragments into phylogenetic groups and then predicting TISs independently for each group in an unsupervised manner. As evaluated on experimentally verified TISs, MetaTISA greatly improves the accuracies of TIS prediction of current gene-finders.
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