期刊
SURVEY OF OPHTHALMOLOGY
卷 45, 期 3, 页码 175-194出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0039-6257(00)00151-X
关键词
embryogenesis; genetic disorders; microphthalmia; ocular coloboma; ocular colobomata
Ocular colobomata present diagnostic and therapeutic challenges in patients of all ages, but especially in young children. The typical coloboma, caused by defective closure of the fetal fissure, is located in the inferonasal quadrant, and it may affect any Dart of the globe traversed by the fissure from the iris to the optic nerve. Ocular colobomata are often associated with microphthalmia, and they may be idiopathic or associated with various syndromes. Types and severity of complications vary depending on the location and size of the colobomata. This article reviews the pathogeneses, categorization, genetic bases, differential diagnoses and management of ocular coloboma. (Surv Ophthalmol 45: 175-194, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.).
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