期刊
BIOINFORMATICS
卷 24, 期 13, 页码 1538-1539出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btn226
关键词
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Malin is a software package for the analysis of eukaryotic gene structure evolution. It provides a graphical user interface for various tasks commonly used to infer the evolution of exonintron structure in protein-coding orthologs. Implemented tasks include the identification of conserved homologous intron sites in protein alignments, as well as the estimation of ancestral intron content, lineage-specific intron losses and gains. Estimates are computed either with parsimony, or with a probabilistic model that incorporates rate variation across lineages and intron sites.
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