期刊
BIOGERONTOLOGY
卷 14, 期 6, 页码 573-590出版社
SPRINGER
DOI: 10.1007/s10522-013-9469-9
关键词
Adult stem cells; Aging; Regeneration; Age-related diseases; Stem cell therapy
资金
- EU [RESOLVE FP7-HEALTH-F4-2008-202047, PIAP-GA-2008-230675, FP7-HEALTH-2011-278418, EpihealthNet PITN-GA-2012-317146, PITN-GA-2010-264257, PIAP-GA-2009-251186, AniStem PIAPP-GA-2011-286264]
- Research Centre of Excellence [17586-4/2013/TUDPOL]
- Bonus Resolve [OMFB-01660/2009]
Aging is accompanied by reduced regenerative capacity of all tissues and organs and dysfunction of adult stem cells. Notably, these age-related alterations contribute to distinct pathophysiological characteristics depending on the tissue of origin and function and thus require special attention in a type by type manner. In this paper, we review the current understanding of the mechanisms leading to tissue-specific adult stem cell dysfunction and reduced regenerative capacity with age. A comprehensive investigation of the hematopoietic, the neural, the mesenchymal, and the skeletal stem cells in age-related research highlights that distinct mechanisms are associated with the different types of tissue stem cells. The link between age-related stem cell dysfunction and human pathologies is discussed along with the challenges and the future perspectives in stem cell-based therapies in age-related diseases.
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