期刊
BIOGERONTOLOGY
卷 10, 期 2, 页码 191-202出版社
SPRINGER
DOI: 10.1007/s10522-008-9167-1
关键词
Aging; Humans; CD8(+) T cell; Gene expression
资金
- Austrian Science Fund [S9308-B05, S9309-B05]
We isolated highly purified CD8(+)CD28(+) and CD8(+)CD28(-) T cell populations from healthy young and elderly persons for gene expression profiling using Affymetrix oligonucleotide microarrays. We demonstrate that the gene expression profile of CD8(+)CD28(-) T cells is very similar in young and elderly persons. In contrast, CD8(+)CD28(+) in elderly differ from CD8(+)CD28(+) in young persons. Hierarchical clustering revealed that CD8(+)CD28(+) in elderly are located between CD8(+)CD28(+) in young and CD8(+)CD28(-) (young and old) T cells regarding their differentiation state. Our study demonstrates a dichotomy of gene expression levels between CD8(+)CD28(+) T cells in young and elderly persons but a similarity between CD8(+)CD28(-) T cells in young and elderly persons. As CD8(+)CD28(+) T cells from elderly and young persons are distinct due to a different composition of the population, these results suggest that the gene expression profile does not depend on chronological age but depends on the differentiation state of the individual cell types.
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