期刊
BIOGERONTOLOGY
卷 9, 期 5, 页码 317-323出版社
SPRINGER
DOI: 10.1007/s10522-008-9143-9
关键词
human fertility; longevity; antagonist pleiotropy; APOE polymorphism; PPAR-gamma polymorphism
资金
- University 'La Sapienza'
The present study investigated for a possible effect on fertility of four longevity candidate genes (ACE, PON1, PPAR-gamma, APOE) in order to determine whether they have a pleiotropic action at different life ages. The study population was 151 healthy unrelated subjects. Only PPAR-gamma and APOE showed an effect on fertility. The PPAR-gamma Pro/Ala genotype, which had showed an association with longevity only in men, was found associated only in men with having produced more children (6.1 +/- 3.3) than the Pro/Pro genotype (3.3 +/- 1.9; P = 0.001). APOE*2 allele, which has been consistently associated with longevity, was confirmed to be associated with the lowest fertility (P = 0.03). The logistic regression analysis indicated that APOE and PPAR-gamma polymorphisms may be considered independent determinants of reproductive efficiency. These data suggest that the APOE*2 allele follows the model of antagonist pleiotropy, while the PPAR-gamma Pro/Ala genotype seems to exert beneficial effects both early in life and in advanced age in a gender-specific way.
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