The postulate of local isotropy (PLI) is tested in a wind tunnel uniform shear flow in which the Reynolds number is varied over the range 100 less than or equal to R(lambda)less than or equal to 1, 100(6.7x10(2)less than or equal to R(l)less than or equal to 6.3x10(4)). The high R-lambda is achieved by using an active grid [Mydlarski and Warhaft, J. Fluid Mech. 320, 331 (1996)] in conjunction with a shear generator. We focus on the increments of the longitudinal velocity fluctuations in the direction of the mean shear. PLI requires that odd order moments of these quantities approach zero as R-lambda-->infinity. Confirming the lower Reynolds number measurements of Garg and Warhaft [Phys. Fluids 10, 662 (1998)], we show that the skewness of partial derivative u/partial derivative y decreases as R-lambda(-0.5) (with a value of 0.2 at R(lambda)similar to 1000). Although the decrease is slower than classical scaling arguments suggest, the result is consistent with PLI, indicating a negligible value at high R-lambda. However, the normalized fifth moment, <(partial derivative u/partial derivative y)(5)>/<(partial derivative u/partial derivative y)(2)>(5/2), is of order 10, and shows no diminution with Reynolds number, while the normalized seventh moment increases with R-lambda. These dissipation range results are inconsistent with PLI. Within the inertial subrange we show that all the odd order moments of the increments of Delta u(y) are nonzero, exhibiting scaling ranges. Here, the skewness structure function has a value similar to 0.5 indicating that in the inertial subrange significant anisotropy is evident even at the third moment level. Fifth- and seventh-order inertial subrange skewness structure functions are of order 10 and 100, respectively. The results show that PLI is untenable, both at dissipation and inertial scales, at least to R(lambda)similar to 1000, and suggest it is unlikely to be so even at higher Reynolds numbers. (C) 2000 American Institute of Physics. [S1070-6631(00)50512-1].
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