期刊
APOPTOSIS
卷 5, 期 5, 页码 415-418出版社
SPRINGER
DOI: 10.1023/A:1009616228304
关键词
apoptosis; death receptors; inflammation; reactive oxygen species (ROS)
Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells.
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