期刊
INTERNATIONAL JOURNAL OF OBESITY
卷 24, 期 -, 页码 S8-S10出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.ijo.0801492
关键词
PPAR gamma; adipogenesis; fat cells; energy balance
There has been a great deal of recent progress in our understanding of the transcriptional control of adipogenesis. Current data suggest that fat cell differentiation involves an interplay between the C/EBP family of transcription factors and PPAR gamma, The thermogenic program of brown fat cells may also include a contribution from a new coactivator, PGC-1. Recent data suggests that this cosactivator is responsible for activation of thermogenesis and oxidative metabolism in both brown fat and muscle. The PGC-1 dependent program includes both mitochondrial biogenesis and tissue-specific expression of uncoupling proteins.
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