期刊
NUCLEIC ACIDS RESEARCH
卷 28, 期 21, 页码 4232-4236出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/28.21.4232
关键词
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Sensitivity of meiotic cells to DNA damaging agents is little understood. We have demonstrated that the meiotic-pachytene nuclei in the Caenorhabditis elegans gonad are hyper-resistant to X-ray irradiation, but not to UV irradiation, whereas the early embryonic cells after fertilization and the full grown oocytes are not. The Ce-rdh-1 gene [RAD51, DMC1 (LIM15), homolog 1 or Ce-rad-51], which is essential for the meiotic recombination, is the only bacterial recA-like gene in the nematode genome, and is strongly expressed in the meiotic cells. Following silencing of the Ce-rdh-1 gene by RNA interference, the meiotic cells become more sensitive to X-ray irradiation than the early embryonic cells. This is the first report that meiotic cells are hyper-resistant to DNA strand breaks due to the high level of expression of the enzyme(s) involved in meiotic homologous recombination.
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