期刊
IMMUNITY
卷 13, 期 5, 页码 599-609出版社
CELL PRESS
DOI: 10.1016/S1074-7613(00)00060-1
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资金
- NCRR NIH HHS [T32 RR007019, T32 RR07019] Funding Source: Medline
- NIAID NIH HHS [K08 AI001445-04, K08 AI001445-05, K08 AI001445-06] Funding Source: Medline
- PHS HHS [1 K08 AJ01445-01] Funding Source: Medline
Lnk is an SH2 domain-containing adaptor protein expressed preferentially in lymphocytes. To illuminate the importance of Lnk, we generated Ink(-/-) mice. Whereas T cell development was unaffected, pre-B and immature B cells accumulated in the spleens. In the bone marrow, B-lineage cells were proportionately increased, reflecting enhanced production of pro-B cells that resulted in part from hypersensitivity of precursors to SCF, the ligand for c-kit. Hence, Lnk ordinarily acts to regulate B cell production. Further characterization of Ink(-/-) mice also revealed that full-length Lnk is a 68 kDa protein containing a conserved proline-rich region and a PH domain. Lnk is a representative of a multigene adaptor protein family whose members act, by analogy with Lnk, to modulate intracellular signaling.
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