期刊
MECHANISMS OF DEVELOPMENT
卷 98, 期 1-2, 页码 187-191出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(00)00444-5
关键词
ten-m; ten-a; neurestin; odz; DOC4; teneurin-1; chick embryo; somite; limb development; morphogenesis; in situ hybridization
The teneurins are a family of four transmembrane proteins expressed in the developing vertebrate nervous system, though the Drosophila tenurinn ten-m is also a pair-rule gene. Whole-mount in situ hybridization was used to localize teneurin-4 transcripts in the chicken embryo. The earliest signal is detected at stage 19 in the somites and limb buds. By stage 20 teneurin-4 transcripts are detected in temporal periocular mesenchyme, branchial arches, diencephalon and somites. Teneurin-4, expression in the limbs changes dramatically during development. Between stages 19 and 21 teneurin-4 expression is concentrated proximally in the zone of polarizing activity. Between stages 24 and 26 teneurin-4 is expressed in the mesenchyme of the anterodistal part of the limb. As in Drosophila, vertebrate teneurins are expressed not only in the nervous system, but also in non-neuronal tissues during pattern formation. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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