期刊
HEARING RESEARCH
卷 149, 期 1-2, 页码 189-198出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-5955(00)00182-9
关键词
cisplatin; ototoxicity; endocochlear potential; cochlear microphonics; chinchilla
资金
- NIDCD NIH HHS [R01DC02396] Funding Source: Medline
The purpose of this study was to investigate how the hair cells and stria vascularis are affected at the onset of cisplatin ototoxicity. The effects on the endocochlear potential (EP) and the cochlear microphonics (CM) were observed simultaneously in two groups of adult chinchillas receiving as follows: (1) 5 mu l of cisplatin (1 mg/ml) in normal saline, and (2) 5 mu l of normal saline on round window. The EP and the CM were recorded for 12-14 h after cisplatin application, and morphological changes were assessed using scanning electron microscopy. Both the EP and the CM amplitude demonstrated a profound reduction, and a very strong correlation was observed between these two values during this time period. Although the reduction of the EP and the CM was observed by 12-14 h, only very slight degeneration of outer hair cells was seen at that time. These data suggested that a reduction of the EP which was caused by the alteration of the stria vascularis might be primarily responsible for very early changes in cochlear function after topical cisplatin application, while later changes were the direct result of hair cell damage. (C) 2000 Elsevier Science B.V. All rights reserved.
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