期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 11, 期 9, 页码 375-378出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S1043-2760(00)00305-2
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Pancreatic beta cells are responsible for maintaining the body's glucose levels within a very narrow range; their population is dynamic, with compensatory changes to maintain euglycemia Throughout the lifetime of a mammal, low levels of beta -cell replication and apoptosis are balanced and result in a slowly increasing mass of beta cells. The emphasis in this review is on recent insights on the natural history of the beta cell in a normal pancreas: sources of renewal, survival and changes in differentiation.
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