期刊
ALLERGY
卷 55, 期 11, 页码 1011-1018出版社
WILEY
DOI: 10.1034/j.1398-9995.2000.00685.x
关键词
atopic dermatitis; CD30; human Th1/Th2 cells; interferon-gamma; interleukin-4
Th2 clones have been reported to express CD30 preferentially, but whether T cells producing Th2-type cytokines may favor CD30 expression in the in who state remains unknown. We investigated the expression of CD30 on circulating T cells in atopic dermatitis (AD) as a Th2-dominated disorder. Peripheral blood mononuclear cells were prepared from 51 AD patients and 14 nonatopic controls, and their phenotypes were analyzed with flow cytometry. Cytokine production by stimulated CD4(+) T cells was also assessed by the single-cell-staining method. Flow cytometric analysis clearly revealed that CD30(+) T cells were identifiable in the blood of AD patients with greater frequency compared to controls. The important finding was that CD30 expression was restricted to a small but substantial population of memory (CD45RO(+)) CD4(+) T cells, but not CD8(+) ones. In AD patients, it was demonstrated that the percentages of CD30(+) cells within CD45RO(+) CD4(+) T cells correlated well with the disease severity, serum IgE levels, peripheral eosinophil counts, and tendency toward Th2-dominant cytokine pattern as determined by the ratio of interleukin-4 to interferon-gamma production. This study suggests that CD30 expression in circulating T cells might serve as an in vivo marker for the Th2-dominated condition.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据