期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 67, 期 3, 页码 537-544出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0091-3057(00)00396-8
关键词
conditioned flavor preference; sham-feeding preparation; dopamine; D-1 receptor; D-2 receptor; SCH23390; raclopride; expression studies; acquisition studies
资金
- NIMH NIH HHS [MH-00983] Funding Source: Medline
The present study examined the effects of D-1 and D-2 antagonists on flavor-preference conditioning by the sweet taste of sucrose. All sessions were conducted under sham-feeding conditions to minimize post-ingestive influences. The rats were trained in alternating, one-bottle sessions to sham-feed a 16% sucrose solution containing one novel flavor (CS+) and a less-preferred 0.2% saccharin solution containing a different flavor (CS -). Three groups of food-restricted rats were treated with either vehicle (control group), the D-1 antagonist, SCH23390 (200 nmol/kg), or the D-2 antagonist, raclopride (200 nmol/kg) during one-bottle training. A fourth group (yoked group) was vehicle-treated and its training intakes were matched to that of the D-1 and D-2 drug groups. Preferences were assessed in two-bottle tests with the CS+ and CS - flavors presented in mixed 8% sucrose + 0.10% saccharin solutions following systemic doses of 0, 200, or 800 nmol/kg of either the D-1 or D-2 antagonists. All groups significantly preferred the CS+ flavor in vehicle tests, although the preferences were weaker in the D-1, D-2, and yoked groups compared to the control group. All groups selectively reduced their CS+ intakes when treated with either D-1 or D-2 antagonists during two-bottle testing, and the CS+ preference was blocked at the higher doses. These data show that D-1 and D-2 receptor antagonists block the expression of a sucrose-conditioned preference, but produces substantially lesser effects upon the acquisition of this form of flavor conditioning. (C) 2000 Elsevier Science Inc. All rights reserved.
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