期刊
BIOFOULING
卷 30, 期 8, 页码 883-891出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/08927014.2014.940921
关键词
BODIPY; photodynamic treatment; Pseudomonas aeruginosa
资金
- University of Insubria (Fondo di Ateneo per la Ricerca)
- Danish Council for Independent Research
Photodynamic therapy (PDT) combines the use of organic dyes (photosensitizers, PSs) and visible light in order to elicit a photo-oxidative stress which causes bacterial death. GD11, a recently synthesized PS belonging to the boron-dipyrro-methene (BODIPY) class, was demonstrated to be efficient against planktonic cultures of Pseudomonas aeruginosa, causing a 7 log unit reduction of viable cells when administered at 2.5 mu M. The effectiveness of GD11 against P. aeruginosa biofilms grown in flow-cells and microtiter trays was also demonstrated. Confocal laser scanning microscopy of flow-cell-grown biofilms suggests that the treatment has a biocidal effect against bacterial biofilm cells.
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