期刊
CLINICAL GENETICS
卷 58, 期 5, 页码 353-363出版社
MUNKSGAARD INT PUBL LTD
DOI: 10.1034/j.1399-0004.2000.580504.x
关键词
embryonic stem cells; X chromosome; Xist gene
X chromosome (X) inactivation is a remarkable biological process including the choice and cis-limited inactivation of one X, as well as the stable maintenance of this silencing by epigenetic chromatin alterations. The process results in females generally being mosaic for two populations of cells - one with each parental X active. In this review, we discuss recent advances in our understanding of how inactivation works, as well as the causes and clinical implications of deviations from random inactivation.
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