期刊
SCIENCE
卷 290, 期 5493, 页码 982-984出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.290.5493.982
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资金
- NCI NIH HHS [CA13106] Funding Source: Medline
- NIGMS NIH HHS [GM41249] Funding Source: Medline
We have identified an activity that is required for transcription of downstream promoter element (DPE)-containing core promoters in vitro. The purified factor was found to be the Drosophila homolog of the transcriptional repressor known as NC2 or Dr1-Drap1. Purified recombinant dNC2 activates DPE-driven promoters and represses TATA-driven promoters. A mutant version of dNC2 can activate DPE promoters but is unable to repress TATA promoters. Thus, the activation and repression functions are distinct. These studies reveal that NC2 (Dr1-Drap1) is a bifunctional basal transcription factor that differentially regulates gene transcription through DPE or TATA box motifs.
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