期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 303, 期 4, 页码 627-640出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1006/jmbi.2000.4152
关键词
homology; protein evolution; pathway evolution; metabolism; TIM barrels
We provide statistically reliable sequence evidence indicating that at least 12 of 23 SCOP (beta alpha)(8) (TIM) barrel superfamilies share a common origin. This includes all but one of the known and predicted TIM barrels found in central metabolism. The statistical evidence is complemented by an examination of the details of protein structure, with certain structural locations favouring catalytic residues even though the nature of their molecular function may change. The combined analysis of sequence, structure and function also enables us to propose a phylogeny of TIM barrels. Based on these data, we are able to examine differing theories of pathway and enzyme evolution, by mapping known TIM barrel folds to the pathways of central metabolism. The results favour widespread recruitment of enzymes between pathways, rather than a backwards evolution model, and support the idea that modern proteins may have arisen from common ancestors that bound key metabolites. (C) 2000 Academic Press.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据