期刊
BIOFACTORS
卷 39, 期 6, 页码 633-643出版社
WILEY
DOI: 10.1002/biof.1128
关键词
obesity; probiotic; gene expression; low calorie diet; T lymphocyte
Probiotics are believed to have interaction with immune cells through sustained effects on gene expression of different cytokines and transcription factors. The present randomized doubled-blind controlled clinical trial was performed recruiting 75 individuals with BMI 25-35, who were randomly assigned to the following three groups: Group 1 (n=25) who consumed regular yogurt as part of a low calorie diet [RLCD], group 2 (n=25) who received probiotic yogurt with a LCD [PLCD] and group 3 (n=25) who consumed probiotic yogurt without LCD [PWLCD] for 8 week. Participants in PLCD and PWLCD groups received 200 g/day yogurt containing Lactobacillus acidophilus La5, Bifidobacterium Bb12, and lactobacillus casei DN001 10(8) cfu/gr. The expression of the FOXP3, T-bet, GATA3, TNF-, IFN-, TGF-, and ROR-t in PBMCs genes were assessed, before and after intervention. In three groups, ROR-t expression was reduced (P=0.007) and FOXP3 was increased (P<0.001). The expression of TNF, TGF, and GATA3 genes did not change among all groups after intervention. Interestingly, the expression of T-bet gene, which was significantly decreased in PLCD and PWLCD groups (P<0.001), whereas gene expression of IFN- decreased in all three groups. Our results suggest that weight loss diet and probiotic yogurt had synergistic effects on T-cell subset specific gene expression in peripheral blood mononuclear cells among overweight and obese individuals. (c) 2013 BioFactors, 39(6):633-643, 2013
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据