期刊
BIOFACTORS
卷 39, 期 4, 页码 374-382出版社
WILEY-BLACKWELL
DOI: 10.1002/biof.1104
关键词
syndecan; extracellular matrix; heparan sulphate; proteoglycan; cell adhesion
资金
- Arthritis Research-UK [19207]
- William Harvey Research Foundation
- Queen Mary University of London, Bart and the London School of Medicine and Dentistry
- Versus Arthritis [19207] Funding Source: researchfish
Syndecans are a four member family of multifunctional transmembrane heparan sulphate bearing cell surface receptors. Each family member has common molecular architecture but a distinct expression profile. Numerous molecular interactions between syndecan heparan sulphate chains, growth factors, cytokines, and extracellular matrix molecules have been reported and syndecans are intimately associated with cell adhesion and migration. Here, we describe the important emerging concept that contained within syndecan extracellular core proteins are adhesion regulatory domains. Cell adhesion is driven by the integrins and syndecan ectodomain adhesion regulatory domains can alter integrin driven cellular responses. Cell adhesion and migration is central to numerous pathologies and an understanding of how syndecan ectodomains influence integrins will lead to novel therapeutic strategies. (c) 2013 BioFactors, 39(4):374-382, 2013
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