期刊
CIRCULATION RESEARCH
卷 87, 期 10, 页码 845-855出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.RES.87.10.845
关键词
K-ATP; protection; mitochondria; ischemia; apoptosis
We are on the brink of harnessing the cell's natural defenses against ischemia and reperfusion injury after years of research into the destructive and protective mechanisms involved. Since the discovery of ischemic preconditioning, the surface receptors and signal transduction pathways underlying this phenomenon have been clarified, but many questions remain about the downstream targets that ultimately protect the cell. ATP-sensitive K+ (K-ATP) channels are thought to play a role in protection, bur their mechanism of action has been unclear. Accumulating evidence now suggests that the location of the K-ATP channels relevant to cytoprotection may be on the mitochondrial inner membrane instead of on the sarcolemma of the cardiac cell. This review discusses recent findings and unanswered questions about the role of K-ATP channels in preconditioning and protection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据