期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 275, 期 45, 页码 35170-35175出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.C000258200
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CBP and its homologue p300 play significant roles in cell differentiation, cell cycle, and anti-oncogenesis, We demonstrated that beta -catenin, recently known as a potent oncogene; and CBP/p300 are associated through its CH3 region, which is a primary target of adenoviral oncoprotein E1A and various nuclear proteins, such as p53, cyclin E, and AP-1, and both are colocalized in the nuclear :bodies. CBP/p300 potentiated Lef-mediated transactivation of beta -catenin, and E1A, a potent inhibitor of CBP/p300, repressed its transactivation. Furthermore, overexpression of stable beta -catenin mutant competitively suppressed the p53-dependent pathway. These may be a key mechanism of beta -catenin involved in oncogenic events underlying disruption of tumor suppressor function through CBP/p300.
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