期刊
BIOFACTORS
卷 38, 期 2, 页码 98-106出版社
WILEY
DOI: 10.1002/biof.199
关键词
Alzheimer's disease; amyloid beta peptide; preclinical Alzheimer's disease; zinc; zinc transporter proteins; mild clinical impairment
资金
- NIH [P30-AG028383, 1RO1-AG16269]
Alzheimer's disease (AD), one of the major causes of disability and mortality in Western societies, is a progressive age-related neurodegenerative disorder. Increasing evidence suggests that the etiology of AD may involve disruptions of zinc (Zn) homeostasis. This review discusses current evidence supporting a potential role of Zn and zinc transporters (ZnTs) in processing of the amyloid beta protein precursor (APP) and amyloid beta (A beta) peptide generation and aggregation.
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