期刊
NUCLEIC ACIDS RESEARCH
卷 28, 期 22, 页码 4474-4478出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/28.22.4474
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资金
- NCI NIH HHS [P01 CA016519, CA16519] Funding Source: Medline
Telomere length and telomerase activity directly affect-the replicative capacity of primary human cells. Some have suggested that telomere length influences organismal lifespan. We compared telomere length distributions in a number of inbred and outbred established mouse strains with those of strains recently derived from wild mice, Telomere length :was considerably shorter in wild-derived strains than in the established strains, We found no correlation of telomere length with lifespan, even among closely related inbred mouse strains. Thus, while telomere length plays a role in cellular lifespan in cultured human cells, it is not a major factor in determining organismal lifespan.
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