Retinoic acid: A key player in immunity

For the past loo years, vitamin A has been implicated as an essential dietary component in host resistance to infectious disease. However, only recently have studies begun to elucidate the cellular and molecular mechanisms of how vitamin A regulates cell-mediated and humoral-mediated immunity. In this review, we present an overview of the recent discoveries of the role that vitamin A and its metabolite, retinoic acid (RA), play in the regulation of immune cells. How RA impacts on leukocyte growth, differentiation, and homing is discussed with special attention to inflammatory responses and solid tumor microenvironment. (C) 2010 International Union of Biochemistry and Molecular Biology, Inc. Volume 36, Number 6, November/December 2010, Pages 430-436. E-mail: rjn@dartmouth.edu