期刊
FEBS LETTERS
卷 485, 期 2-3, 页码 147-152出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)02220-1
关键词
coronin; phosphatidylinositol 3-kinase; phagocytosis; macrophage
Coronin, a 57 kDa actin binding protein elutes with an apparent molecular mass of 400-600 kDa from gel filtration columns. This fraction is not unrelated to the reported 200 kDa complex where coronin is associated with phox proteins of the NADPH-oxidase. Phosphatidylinositol 3-kinase (PI 3-kinase) solubilizes coronin from the 400-600 kDa complex, thus constitutive active PI 3-kinase is sufficient to disrupt the complex, whereas wortmannin stabilizes it. Conversely, the phox protein associated pool of coronin is PI 3-kinase independent. During phagocytosis coronin is recruited together with PI 3-kinase to membranes of nascent and early phagosomes colocalizing with the actin cytoskeleton, confirming that coronin contributes to phagocytosis, (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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