相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells
Weibo Luo et al.
Oncotarget (2015)
A critical role for citrate metabolism in LPS signalling
Luke A. J. O'Neill
BIOCHEMICAL JOURNAL (2013)
AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?
Madhumita Dandapani et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2013)
Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes
Hye-Mi Lee et al.
DIABETES (2013)
Effects of Metformin Versus Glipizide on Cardiovascular Outcomes in Patients With Type 2 Diabetes and Coronary Artery Disease
Jie Hong et al.
DIABETES CARE (2013)
Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells
Yutaka Kurebayashi et al.
GENES TO CELLS (2013)
Induced and Natural Regulatory T Cells in the Development of Inflammatory Bowel Disease
Christopher G. Mayne et al.
INFLAMMATORY BOWEL DISEASES (2013)
Reciprocal Regulation of Protein Kinase and Pyruvate Kinase Activities of Pyruvate Kinase M2 by Growth Signals
Xueliang Gao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Tregs are dysfunctional in vivo in a spontaneous murine model of Crohn's disease
D. Ishikawa et al.
MUCOSAL IMMUNOLOGY (2013)
Metabolism of inflammation limited by AMPK and pseudo-starvation
Luke A. J. O'Neill et al.
NATURE (2013)
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
G. M. Tannahill et al.
NATURE (2013)
Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects
M. A. Pierotti et al.
ONCOGENE (2013)
Low Concentrations of Metformin Selectively Inhibit CD133+ Cell Proliferation in Pancreatic Cancer and Have Anticancer Action
Shanmiao Gou et al.
PLOS ONE (2013)
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
Gopinath Sutendra et al.
FRONTIERS IN ONCOLOGY (2013)
Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase
Chan Sun Park et al.
BIOCHEMICAL PHARMACOLOGY (2012)
Two Phase 2 Trials of the Novel Akt Inhibitor Perifosine in Patients With Advanced Renal Cell Carcinoma After Progression on Vascular Endothelial Growth Factor-Targeted Therapy
Daniel C. Cho et al.
CANCER (2012)
Pyruvate Kinase M2: Multiple Faces for Conferring Benefits on Cancer Cells
Mayumi Tamada et al.
CLINICAL CANCER RESEARCH (2012)
Temsirolimus: a safety and efficacy review
Ronald M. Bukowski
EXPERT OPINION ON DRUG SAFETY (2012)
PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells
David K. Finlay et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase
Xueliang Gao et al.
MOLECULAR CELL (2012)
CANCER METABOLISM When more is less
Lei Jiang et al.
NATURE (2012)
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
Weiwei Yang et al.
NATURE CELL BIOLOGY (2012)
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
Dimitrios Anastasiou et al.
NATURE CHEMICAL BIOLOGY (2012)
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
Charles A. Dinarello et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Epstein-Barr Virus Immortalization of Human B-Cells Leads to Stabilization of Hypoxia-Induced Factor 1 Alpha, Congruent with the Warburg Effect
Suhas Darekar et al.
PLOS ONE (2012)
The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase
Simon A. Hawley et al.
SCIENCE (2012)
PPARs: Interference with Warburg' Effect and Clinical Anticancer Trials
Joseph Vamecq et al.
PPAR RESEARCH (2012)
ACCELERATED PUBLICATION The mitochondrial citrate carrier: a new player in inflammation
Vittoria Infantino et al.
BIOCHEMICAL JOURNAL (2011)
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
Weibo Luo et al.
CELL (2011)
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
Eric V. Dang et al.
CELL (2011)
Emerging Metabolic Targets in Cancer Therapy
Yuhua Zhao et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2011)
Human FoxP3+CD4+ regulatory T cells: their knowns and unknowns
Makoto Miyara et al.
IMMUNOLOGY AND CELL BIOLOGY (2011)
HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
Lewis Z. Shi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS
A. Phillip West et al.
NATURE (2011)
Identification of lysine succinylation as a new post-translational modification
Zhihong Zhang et al.
NATURE CHEMICAL BIOLOGY (2011)
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
Qian Sun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
Jintang Du et al.
SCIENCE (2011)
Otto Warburg's contributions to current concepts of cancer metabolism
Willem H. Koppenol et al.
NATURE REVIEWS CANCER (2011)
Regulation of cancer cell metabolism
Rob A. Cairns et al.
NATURE REVIEWS CANCER (2011)
Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation
Connie M. Krawczyk et al.
BLOOD (2010)
Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo
Ramon C. Sun et al.
BREAST CANCER RESEARCH AND TREATMENT (2010)
Selection of cancer cells with repressed mitochondria triggers colon cancer progression
Maria Sanchez-Arago et al.
CARCINOGENESIS (2010)
被撤回的出版物: Activated macrophages utilize glycolytic ATP to maintain mitochondrial membrane potential and prevent apoptotic cell death(Retracted article. See vol. 24, pg. 1132, 2017)
A. Garedew et al.
CELL DEATH AND DIFFERENTIATION (2010)
Induction of HIF-1α and the glycolytic pathway alters apoptotic and differentiation profiles of activated human T cells
Anis Larbi et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2010)
Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?
Issam Ben Sahra et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
G. L. Semenza
ONCOGENE (2010)
Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells
Matthew G. Vander Heiden et al.
SCIENCE (2010)
Metformin Attenuated the Autoimmune Disease of the Central Nervous System in Animal Models of Multiple Sclerosis
Narender Nath et al.
JOURNAL OF IMMUNOLOGY (2009)
Dichloroacetate induces apoptosis in endometrial cancer cells
Jason Y. Y. Wong et al.
GYNECOLOGIC ONCOLOGY (2008)
Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance
Chun-Wun Lu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R. Christofk et al.
NATURE (2008)
Triggering the succinate receptor GPR91 on dendritic cells enhances immunity
Tina Rubic et al.
NATURE IMMUNOLOGY (2008)
Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation
Wengang Cao et al.
PROSTATE (2008)
Hypoxia, HIF1 and glucose metabolism in the solid tumour
Nicholas C. Denko
NATURE REVIEWS CANCER (2008)
The role of hypoxia-inducible factors in cancer
M. A. Maynard et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2007)
Hypoxia signalling in cancer and approaches to enforce tumour regression
Jacques Pouyssegur et al.
NATURE (2006)
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
I Papandreou et al.
CELL METABOLISM (2006)
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
JW Kim et al.
CELL METABOLISM (2006)
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
MA Selak et al.
CANCER CELL (2005)
Inhibition of inducible nitric-oxide synthase by activators of AMP-activated protein kinase - A new mechanism of action of insulin-sensitizing drugs
G Pilon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle
EO Ojuka
PROCEEDINGS OF THE NUTRITION SOCIETY (2004)
Efficacy of dichloroacetate as a lactate-lowering drug
PW Stacpoole et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2003)
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
K Kondo et al.
CANCER CELL (2002)
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats - Role of increased expression and activity of voltage-gated potassium channels
ED Michelakis et al.
CIRCULATION (2002)
分享论文
