期刊
EXPERIMENTAL CELL RESEARCH
卷 261, 期 1, 页码 44-51出版社
ACADEMIC PRESS INC
DOI: 10.1006/excr.2000.5046
关键词
Rho; Rho-associated kinase (Rho-kinase); myosin-binding subunit (MBS); myosin; actin; Ezrin/radixin/moesin (ERM); adducin; intermediate filament; LIM-kinase; collapsin response mediator protein-2 (CRMP2)
Remarkable progress has been made in understanding effector molecules of small GTPase Rho, especially Rho-associated kinase (Rho-kinase/ROK/ROCK), in the past 5 years. Rho-associated kinase appears to mediate a large proportion of the signals from Rho and regulate dynamic reorganization of cytoskeletal proteins, such as stress fiber and focal adhesion formation. Several substrates of Rho-associated kinase have been reported and their cellular functions unraveled. In this review, we focus on the regulation and cellular functions of Rho-associated kinase. (C) 2000 Academic Press.
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