期刊
NEUROLOGY
卷 55, 期 10, 页码 1577-1578出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.55.10.1577
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The authors report a presenilin 1 (PSEN1) mutation (L113P) in a family with six cases of dementia. The patients had personality changes and behavioral disorders, whereas spatial orientation and praxis were preserved late in the course of the illness. Neuroimaging features were consistent with the diagnosis of frontotemporal dementia. The authors conclude that PSEN1 mutations can be associated with clinical features of frontotemporal dementia.
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