期刊
BIOESSAYS
卷 34, 期 8, 页码 692-700出版社
WILEY-BLACKWELL
DOI: 10.1002/bies.201200014
关键词
ageing; antioxidant defence; longevity; oxidative damage; theories
资金
- Glenn Foundation Award for Research in Biological Mechanisms of Ageing
- UK BBSRC
- UK NIHR Biomedical Research Centre for Ageing and Age-Related Disease
- German Federal Ministry for Education and Research (BMBF) [FKZ 0315584]
- Medical Research Council [G0700718B] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10260] Funding Source: researchfish
The continuing viability of the free-radical theory of ageing has been questioned following apparently incompatible recent results. We show by modelling positional effects of the generation and primary targets of reactive oxygen species that many of the apparently negative results are likely to be misleading. We conclude that there is instead a need to look more closely at the mechanisms by which free radicals contribute to age-related dysfunction in living systems. There also needs to be deeper understanding of the dynamics of accumulation and removal of the various kinds of molecular damage, in particular mtDNA mutations. Finally, the expectation that free-radical damage on its own might cause ageing needs to be relinquished in favour of the recognition that the free-radical theory is just one of the multiple mechanisms driving the ageing process.
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