期刊
ORGANIC LETTERS
卷 2, 期 24, 页码 3865-3868出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol006605h
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资金
- NCRR NIH HHS [RR13030, RR06262] Funding Source: Medline
- NIAID NIH HHS [AI/GM55508] Funding Source: Medline
Phosphoramidite reagents of the naturally occurring modified nucleosides mcm(5)s(2)U and mcm(5)U were synthesized and along with pseudouridine were incorporated into 17-nucleotide lysine tRNA anticodon stem-loop domains. Standard RNA phosphoramidite coupling chemistry allowed us to systematically investigate the thermodynamic effects of nucleoside modification and to correlate thermodynamic trends with qualitative structure effects seen by NMR spectroscopy.
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