期刊
BIOESSAYS
卷 35, 期 3, 页码 183-190出版社
WILEY
DOI: 10.1002/bies.201200111
关键词
bone marrow niche; granulocyte colony-stimulating factor; leukemia; mobilization; Plerixafor; stem cell
资金
- National Health and Medical Research Council [604303]
- Cancer Council of Queensland
- National Health and Medical Research Council
- Cancer Council of NSW
- Rebecca L Cooper Medical Research Foundation
- NHMRC [1027560]
- Cure the Future
Stem cells and their malignant counterparts require the support of a specific microenvironment or niche. While various anti-cancer therapies have been broadly successful, there are growing opportunities to target the environment in which these cells reside to further improve therapeutic efficacy and outcome. This is particularly true when the aim is to target normal or malignant stem cells. The field aiming to target or use the niches that harbor, protect, and support stem cells could be designated as nichotherapy. In this essay, we provide a few examples of nichotherapies. Some have been employed for decades, such as hematopoietic stem cell mobilization, whereas others are emerging, such as chemosensitization of leukemia stem cells by targeting their niche.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据