期刊
BIOESSAYS
卷 33, 期 10, 页码 737-741出版社
WILEY
DOI: 10.1002/bies.201100076
关键词
blood brain barrier; dendritic cells; exosomes; RNAi; stem cells
资金
- Medical Research Council [G0900887] Funding Source: researchfish
- Parkinson's UK [G-0904] Funding Source: researchfish
- Medical Research Council [G0900887] Funding Source: Medline
- Parkinson's UK [G-0904, G-1109] Funding Source: Medline
- MRC [G0900887] Funding Source: UKRI
The demonstration that dendritic cell (DC)-derived exosomes can be exploited for targeted RNAi delivery to the brain after systemic injection provides the first proof-of-concept for the potential of these naturally occurring vesicles as vehicles of drug delivery. As well as being amenable to existing in vivo targeting strategies already in use for viruses and liposomes, this novel approach offers the added advantages of in vivo safety and low immunogenicity. Fulfilment of the potential of exosome delivery methods warrants a better understanding of their biology, as well as the development of novel production, characterisation, targeting and cargo-loading nanotechnologies. Ultimately, exosome-mediated drug delivery promises to overcome important challenges in the field of therapeutics, such as delivery of drugs across otherwise impermeable biological barriers, such as the blood brain barrier, and using patient-derived tissue as a source of individualised and biocompatible therapeutic drug delivery vehicles.
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