期刊
BIOESSAYS
卷 33, 期 5, 页码 368-376出版社
WILEY-BLACKWELL
DOI: 10.1002/bies.201100007
关键词
ERAD; evolution of protein translocation; peroxisomal importomer; secondary plastid; SELMA
资金
- Deutsche Forschungsgemeinschaft
- German research foundation [SFB 593, SFB TR1]
- LOEWE
- German Academic Exchange Service (DAAD)
At first glance the three eukaryotic protein translocation machineries - the ER-associated degradation (ERAD) transport apparatus of the endoplasmic reticulum, the peroxisomal importomer and SELMA, the pre-protein translocator of complex plastids - appear quite different. However, mechanistic comparisons and phylogenetic analyses presented here suggest that all three translocation machineries share a common ancestral origin, which highlights the recycling of pre-existing components as an effective evolutionary driving force.
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