期刊
BIOESSAYS
卷 32, 期 4, 页码 322-331出版社
WILEY
DOI: 10.1002/bies.200900147
关键词
auxotrophy; biosafety; synthetic biology; xenobiology; xeno nucleic acids
资金
- FWF [I215-B17]
- EC-FP7 [KBBE-2009, 212894]
- Austrian Ministry of Science GEN-AU [GZ BMWF-200.184/0001-II/1a/2008]
- Austrian Science Fund (FWF) [I 215] Funding Source: researchfish
- Austrian Science Fund (FWF) [I215] Funding Source: Austrian Science Fund (FWF)
Synthetic biologists try to engineer useful biological systems that do not exist in nature. One of their goals is to design an orthogonal chromosome different from DNA and RNA, termed XNA for xeno nucleic acids. XNA exhibits a variety of structural chemical changes relative to its natural counterparts. These changes make this novel information-storing biopolymer invisible to natural biological systems. The lack of cognition to the natural world, however, is seen as an opportunity to implement a genetic firewall that impedes exchange of genetic information with the natural world, which means it could be the ultimate biosafety tool. Here I discuss, why it is necessary to go ahead designing xenobiological systems like XNA and its XNA binding proteins; what the biosafety specifications should look like for this genetic enclave; which steps should be carried out to boot up the first XNA life form; and what it means for the society at large.
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