期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 11, 期 4, 页码 321-333出版社
ELSEVIER SCI LTD
DOI: 10.1016/S1359-6101(00)00010-1
关键词
interferon-gamma; interferon-gamma receptor deficiency; interleukin-12; tuberculosis; mycobacteria
A genetic component to human mycobacterial disease susceptibility has long been postulated. Over the past five years, mutations in the interferon-gamma (IFN gamma) receptor, IL-12 receptor beta 1 (IL-12R beta 1), and IL-12 p40 genes have been recognized. These mutations are associated with heightened susceptibility to disease caused by intracellular pathogens including nontuberculous mycobacteria, vaccine-associated bacille Calmette Guerin (BCG), Salmonella species, and some viruses. We describe the genotype-phenotype correlations in IFN gamma receptor, IL-12R beta 1, and IL-12 p40 deficiency, and discuss how study of these diseases has enhanced knowledge of human host defense against mycobacteria and other intracellular pathogens. Published by Elsevier Science Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据