期刊
CURRENT OPINION IN IMMUNOLOGY
卷 12, 期 6, 页码 664-669出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S0952-7915(00)00160-6
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The production of pathogenic autoantibodies in organ-specific autoimmune diseases is largely T cell dependent. For many of these diseases, the precise specificities and cytokine profiles of the T cells that respond to the corresponding autoantigens have now been identified. This knowledge has been exploited to treat some models of antibody-mediated autoimmunity using peptides corresponding to the dominant helper epitopes, giving impetus to the development of a similar approach in the equivalent human diseases.
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