期刊
BIOESSAYS
卷 30, 期 11-12, 页码 1075-1083出版社
JOHN WILEY & SONS INC
DOI: 10.1002/bies.20843
关键词
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资金
- NINDS NIH HHS [R37 NS048392, R01 NS048392-04, R01 NS048392] Funding Source: Medline
The ubiquitin proteasome system is a potent regulatory mechanism used to control protein stability in numerous cellular processes, including neural development. Many neurodegenerative diseases are featured by the accumulation of UPS-associated proteins, suggesting the UPS dysfunction may be crucial for pathogenesis. Recent experiments have highlighted the UPS as a key player during synaptic development. Here we summarize recent discoveries centered on the role of the UPS in synapse remodeling and draw attention to the potential link between the synaptic UPS dysfunction and the pathology of neurodegenerative diseases. BioEssays 30:10751083, 2008. (C) 2008 Wiley Periodicals, Inc.
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