期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 24, 期 8, 页码 843-854出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0149-7634(00)00041-5
关键词
pain; nociception; age differences; ageing; pain models; mid-life; rat; antinociception; stress induced analgesia; hypothalamic-pituitary-adrenal axis; endogenous pain inhibition
Much remains to be learned about the effects of ageing on pain. Studies of life-span changes in nociception and pain behaviours in the rat are equivocal making it difficult to draw firm conclusions. This paper reviews the available data and finds that age differences in nociception may be dependent on the pain test employed. Specifically, reflexive responses to nociceptive stimuli do not change with age while there may be no change or a linear decrease with age on more highly organized tests of nociception. Interestingly, age differences in pain behaviours on models of tissue injury and inflammation may not be linear. It is shown that important changes that begin at midlife in neuroanatomy, neurochemistry and endogenous pain inhibition may be associated with alterations in pain sensitivity. Several testable hypotheses which might encourage future research in this domain are developed throughout this paper. (C) 2000 Published by Elsevier Science Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据