期刊
ANALYTICA CHIMICA ACTA
卷 877, 期 -, 页码 19-32出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2015.01.034
关键词
Signal amplification; Biosensor; Polymerization; Polymeric DNA dendrimers; Conjugated polymers; Atom transfer radical polymerization
资金
- National Natural Science Foundation of China [20875013, 21175021, 21375014]
Demand is increasing for ultrasensitive bioassays for disease diagnosis, environmental monitoring and other research areas. This requires novel signal amplification strategies to maximize the signal output. In this review, we focus on a series of significant signal amplification strategies based on polymeric nanocomposites and polymerization. Some common polymers are used as carriers to increase the local concentration of signal probes and/or biomolecules on their surfaces or in their interiors. Some polymers with special fluorescence and optical properties can efficiently transfer the excitation energy from a single site to the whole polymer backbone. This results in superior fluorescence signal amplification due to the resulting collective effort (integration of signal). Recent polymerization-based signal amplification strategies that employ atom transfer radical polymerization (ATRP) and photo-initiated polymerization are also summarized. Several distinctive applications of polymers in ultrasensitive bioanalysis are highlighted. (C) 2015 Elsevier B.V. All rights reserved.
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