期刊
BRAIN
卷 123, 期 -, 页码 2423-2431出版社
OXFORD UNIV PRESS
DOI: 10.1093/brain/123.12.2423
关键词
brain iron; idiopathic Parkinson's disease; PRIME MRI sequence
dIron content of the basal ganglia was investigated in 25 patients with idiopathic Parkinson's disease and 14 matched healthy control subjects using a partially refocused interleaved multiple echo sequence on a 1.5 Tesla MRI system, R-2* (1/T-2*) and R-2' (1/T-2') relaxation rates were higher in the substantia nigra of patients with Parkinson's disease, which indicates that iron content is elevated in this region. R-2' was lower in the putamen, indicating reduced iron levels; reduction in this region was positively correlated with disease duration. Iron-related oxidative stress may contribute to the neurodegeneration of Parkinson's disease, which may lead to alterations in the iron levels of the striatum, We describe a simple, noninvasive technique for measuring iron content.
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