期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 10, 期 6, 页码 649-655出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-440X(00)00146-9
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Research in apoptosis has established a central role for caspases. The recent determination of structures of caspase-1, caspase-3 and caspase-8, together with biochemical studies, has greatly enhanced our understanding of the structure, function and specificity of these enzymes. This provides a basis for the further elucidation of the biological role of caspases and a guide to the design of selective inhibitors to treat caspase-mediated diseases.
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