期刊
MICROBES AND INFECTION
卷 2, 期 15, 页码 1891-1904出版社
EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S1286-4579(00)01337-X
关键词
fever; sepsis; infection; host defense
资金
- NIAID NIH HHS [R01 AI42217] Funding Source: Medline
Sepsis is a highly lethal clinical syndrome characterized by a systemic inflammatory response to infection. Fever, a non-specific acute-phase response, has been associated with improved survival and shortened disease duration in non-life-threatening infections. However, the influence of fever and the effects of antipyresis in patients with sepsis has not been prospectively studied in humans. This payer reviews the state of our knowledge concerning the biological effects of fever in infected hosts and the influence of fever and antipyretic therapy on survival during sepsis in experimental models and in man. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
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