期刊
BIOELECTROMAGNETICS
卷 31, 期 5, 页码 361-370出版社
WILEY
DOI: 10.1002/bem.20566
关键词
muscle force; high-voltage pulsing; electroporation; calcium dynamics; modeling
资金
- Department of the Navy
A systems-level model analysis of neuromuscular response to external electrical stimulation is presented. Action potential (AP) generation, dynamics of voltage-based calcium release at the motor endplates controlled by the arrival of APs, and muscle force production are all comprehensively included. Numerical predictions exhibit trends that are qualitatively similar to measurements of muscle response in rats from a burst of cortical stimulation and a nanosecond impulse. Modulation of neural membrane conductances (including possible electroporation) that alters the neural impulse generation frequency is hypothesized as a possible mechanism leading to observed changes in muscle force production. Other possibilities such as calcium release at nerve end endings also exist. It is also proposed that multipulsing strategies and changing the electric field direction by using multielectrode systems would be useful. Bioelectromagnetics 31:361-370, 2010. (C) 2010 Wiley-Liss. Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据