期刊
JOURNAL OF NEUROTRAUMA
卷 17, 期 12, 页码 1205-1217出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/neu.2000.17.1205
关键词
allodynia; behavior; chronic pain; pain; spinal cord injury
资金
- NINDS NIH HHS [NS 11255, NS 39161, P01 NS011255, R01 NS054765] Funding Source: Medline
Spinal cord injury (SCI) often results in abnormal pain syndromes in patients. We present a recently developed SCI mammalian model of chronic central pain in which the spinal cord is contused at T8 using the NYU impactor device (10-g rod, 2,0-mm diameter, 12,5-mm drop height), an injury which is characterized behaviorally as moderate. Recovery of locomotor function was assessed with an open field test and scored using the open field test scale (BBB scale). Somatosensory tests of paw withdrawal responses accompanied by supraspinal responses to both mechanical punctate (von Frey hairs) and nonpunctate (4 mm diameter blunt probe) as well as thermal (radiant heat) peripheral stimuli were performed. Comparisons at the level of the individual animal between precontusion and postcontusiom responses indicated significant increases in reactions to low threshold punctate mechanical stimuli, non-punctate stimuli and thermal stimuli (p < 0,05), To demonstrate the validity of this model as a central pain model, gabapentin, an agent used clinically for central pain, was given i.p, at 10 or 30 mg/kg, Gabapentin treatment significantly and reversibly changed the responses, consistent with the attenuation of the abnormal sensory behavior, and the attenuated responses lasted for the duration of the drug effect (up to 6 h), These results support the use of the spinal contusion model in the study of chronic central pain after SCI.
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